Antibioticoterapia y microorganismos asociados a infección por mordedura de serpientes en Costa Rica y Latinoamérica
Contenido principal del artículo
Keywords
mordedura de serpiente, Bothrops, infección, antibiótico
Resumen
Bothrops asper es la principal causa de accidentes ofídicos en Costa Rica. Actualmente, no existe un consenso claro sobre el uso de antibioticoterapia empírica, debido a la heterogeneidad en los criterios clínicos para diagnosticar la infección y la diversidad de microorganismos potencialmente involucrados. El objetivo de este artículo es analizar los tratamientos antibióticos empleados en casos de infección por mordedura de serpiente y determinar los principales agentes patógenos identificados en dichas infecciones en la región.
Citas
1. Brenes-Chacón H, Gutiérrez J, Camacho-Badilla K, Soriano-Fallas A, Ulloa-Gutierrez R, Valverde-Muñoz K et al. Snakebite envenoming in children: A neglected tropical disease in a Costa Rican pediatric tertiary care center. Acta Tropica. 2019;200:105176. Disponible en: https://europepmc.org/article/med/31526777
2. Gutiérrez J. Snakebite envenomation in Central America. Epidemiology, pathophysiology and treatment. In: Mackessy S, ed. by. Handbook of Venoms and Toxins of Reptiles. 2nd ed. Boca Raton, Florida: CRC Press/Taylor and Francis Group; 2021. p. 543-558. Disponible en: https://www.taylorfrancis.com/chapters/edit/10.1201/9780429054204-41/snakebite-envenomation-central-america-jos%C3%A9-mar%C3%ADa-guti%C3%A9rrez
3. Houcke S, Resiere D, Lontsingoula GR, et al. Characteristics of Snakebite-Related Infection in French Guiana. Toxins (Basel). 2022;14(2):89. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878173/
4. Sasa M, Segura Cano S. New insights into snakebite epidemiology in Costa Rica: A retrospective evaluation of medical records. Toxicon: X. 2020;7:100055. Disponible en: https://www.sciencedirect.com/science/article/pii/S2590171020300333
5. Arroyo O, Rojas G, Gutiérrez J. Envenenamiento por mordedura de serpiente en Costa Rica en 1996: Epidemiología y consideraciones clínicas. Acta Médica Costarricense. 1999;41(4):23-29. Disponible en: https://actamedica.medicos.cr/index.php/Acta_Medica/article/view/528
6. Gutiérrez J, Calvete J, Habib A, Harrison R, Williams D, Warrell D. Snakebite envenoming. Nature Reviews Disease Primers. 2017;3(1). Disponible en: https://pubmed.ncbi.nlm.nih.gov/28905944/
7. Brenes-Chacón H, Ulloa-Gutierrez R, Soriano-Fallas A, Camacho-Badilla K, Valverde-Muñoz K, Ávila-Agüero ML. Bacterial Infections Associated with Viperidae Snakebites in Children: A 14-Year Experience at the Hospital Nacional de Niños de Costa Rica. Am J Trop Med Hyg. 2019;100(5):1227-1229. doi:10.4269/ajtmh.18-1015. Disponible en: https://pubmed.ncbi.nlm.nih.gov/30915952/
8. Criales J, Arguedas A. Infecciones bacterianas de tejidos blandos en niños mordidos por serpientes, en el Hospital Nacional de Niños, entre enero de 1988 y diciembre de 1992. Revista Medica Hospital Nacional de Niños Costa Rica. 1994;29:31-36.
9. Mendes V, Pereira H, Elias I, Soares G, Santos M, Talhari C et al. Secondary infection profile after snakebite treated at a tertiary referral center in the Brazilian Amazon. Revista da Sociedade Brasileira de Medicina Tropical. 2022;55. Disponible en: https://www.scielo.br/j/rsbmt/a/nJgnpJHgkWbmmY4DpxCZY4B/abstract/?lang=en
10. Résière D, Olive C, Kallel H, Cabié A, Névière R, Mégarbane B, Gutiérrez JM, Mehdaoui H. Oral Microbiota of the Snake Bothrops lanceolatus in Martinique. International Journal of Environmental Research and Public Health. 2018; 15(10):2122. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209983/
11. Jorge M, Mendonça J, Ribeiro L, Silva M, Kusano E, Cordeiro C. Flora bacteriana da cavidade oral, presas e veneno de Bothrops jararaca: possível fonte de infecção no local da picada. Revista do Instituto de Medicina Tropical de São Paulo. 1990;32(1):6-10. Disponible en: https://www.scielo.br/j/rimtsp/a/sRKZg5CXftGXbRTRyLLP84H/abstract/?lang=pt
12. Arroyo O, Bolaños R, Muñoz G. The bacterial flora of venoms and mouth cavities of Costa Rican snakes. Bull Pan Am Health Organ. 1980;14(3):280-285. https://pubmed.ncbi.nlm.nih.gov/7459511/
13. Artavia-León A, Romero-Guerrero A, Sancho-Blanco C, Rojas N, Umaña-Castro R. Diversity of Aerobic Bacteria Isolated from Oral and Cloacal Cavities from Free-Living Snakes Species in Costa Rica Rainforest. Int Sch Res Notices. 2017;2017:8934285. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585637/
14. Saravia-Otten P, Gutierrez JM, Arvidson S, Thelestam M, Flock JI. Increased infectivity of Staphylococcus aureus in an experimental model of snake venom-induced tissue damage. J Infect Dis. 2007;196(5):748-754. Disponible en: https://pubmed.ncbi.nlm.nih.gov/17674318/
15. Andrade J, Pinto R, Andrade A, Martelli C, Zicker F. Estudo bacteriológico de abscessos causados por picada de serpentes do genero bothrops. Revista do Instituto de Medicina Tropical de São Paulo. 1989;31(6):363-367. Disponible en: https://www.scielo.br/j/rimtsp/a/KV8g3tLLGJFcxPRKhRbjTMr/?lang=pt
16. Jorge MT, Ribeiro LA, da Silva ML, Kusano EJ, de Mendonça JS. Microbiological studies of abscesses complicating Bothrops snakebite in humans: a prospective study. Toxicon. 1994;32(6):743-748. Disponible en: https://pubmed.ncbi.nlm.nih.gov/7940580/
17. Resiere D, Gutiérrez JM, Névière R, Cabié A, Hossein M, Kallel H. Antibiotic therapy for snakebite envenoming. J Venom Anim Toxins Incl Trop Dis. 2020;26:e20190098. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011479/
18. Wagener M, Naidoo M, Aldous C. Wound infection secondary to snakebite. S Afr Med J. 2017;107(4):315-319. Disponible en: https://pubmed.ncbi.nlm.nih.gov/28395682/
19. Muñoz PA, Ovares AC. Antibioticoterapia profiláctica en el accidente ofídico: evidencia actual. Rev Med Cos Cen. 2010;67(593):251-254.
20. Stevens, D.L.; Bisno, A.L.; Chambers, H.F.; Dellinger, E.P.; Goldstein, E.J.C.; Gorbach, S.L.; Hirschmann, J.V.; Kaplan, S.L.; Montoya, J.G.; Wade, J.C. Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections: 2014 Update by the Infectious Diseases Society of America. Clin. Infect. Dis. 2014, 59, 147–159. Disponible en: https://academic.oup.com/cid/article/59/2/e10/2895845
21. Sachett JAG, da Silva IM, Alves EC, et al. Poor efficacy of preemptive amoxicillin clavulanate for preventing secondary infection from Bothrops snakebites in the Brazilian Amazon: A randomized controlled clinical trial. PLoS Negl Trop Dis. 2017;11(7):e0005745. Disponible en: https://pubmed.ncbi.nlm.nih.gov/28692641/
22. Instituto Clodomiro Picado. El envenenamiento por mordedura de serpiente en Centroamérica [Internet]. San José, Costa Rica: Facultad de Microbiología, Universidad de Costa Rica; 2009 [cited 13 June 2022]. Disponible en: https://hdl.handle.net/10669/30344
23. Resiere D, Mehdaoui H, Névière R, et al. Infectious Complications Following Snakebite by Bothrops lanceolatus in Martinique: A Case Series. Am J Trop Med Hyg. 2020;102(1):232-240. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947800/
24. T. Jorge S. de A. Nishioka R. B. de M. Aeromonas hydrophila soft tissue infection as a complication of snake bite: report of three cases. Ann Trop Med Parasitol [Internet]. 1998;92(2):213–7. Disponible en: http://dx.doi.org/10.1080/00034989860067
25. Soares Coriolano Coutinho JV, Fraga Guimarães T, Borges Valente B, Gomes Martins de Moura Tomich L. Epidemiology of secondary infection after snakebites in center-west Brazil. PLoS Negl Trop Dis [Internet]. 2023;17(3):e0011167. Disponible en: http://dx.doi.org/10.1371/journal.pntd.0011167
26. Sachett J de AG, Vieira SSC, Soares FGS, Alcântara JA, Carvalho HB de S, da Silva EMG, et al. Treatment of a snakebite injury with secondary bacterial infection: A case study. J Wound Ostomy Continence Nurs [Internet]. 2023;50(3):245–9. Disponible en: http://dx.doi.org/10.1097/won.0000000000000963
27. Cavalcante TTA, de Souza MBS, Neves JCF, Ibiapina HNS, Barbosa FBA, Bentes KO, et al. Inflammatory profile associated with secondary infection from Bothrops atrox snakebites in the Brazilian Amazon. Toxins (Basel) [Internet]. 2023;15(9):524. Disponible en: http://dx.doi.org/10.3390/toxins15090524
28. Larréché S, Bousquet A, da Silva L, Planelles A, Ksas R, Mérens A, et al. Antibiotic susceptibility of cultivable microbiota from the oral cavity of captive Bothrops atrox and Bothrops lanceolatus: Implications for the treatment of snakebite-associated infections in the French departments of America. Infect Dis Now [Internet]. 2023;53(7):104721. Disponible en: https://doi.org/10.1016/j.idnow.2023.104721
29. Brenes-Chacon H, Gutierrez JM, Camacho-Badilla K, Soriano-Fallas A, Ulloa-Gutierrez R, Valverde K, et al. Long-term sequelae secondary to snakebite envenoming: a single centre retrospective study in a Costa Rican paediatric hospital. BMJ Paediatr Open [Internet]. 2020;4(1):e000735. Disponible en: http://dx.doi.org/10.1136/bmjpo-2020-000735
30. Bucaretchi F, Herrera SRF, Hyslop S, Baracat ECE, Vieira RJ. Snakebites by Bothrops spp in children in Campinas, São Paulo, Brazil. Rev Inst Med Trop Sao Paulo [Internet]. 2001;43(6):329–33. Disponible en: http://dx.doi.org/10.1590/s0036-46652001000600006
31. Otero R, Gutiérrez J, Beatriz Mesa M, Duque E, Rodrı́guez O, Luis Arango J, et al. Complications of Bothrops, Porthidium, and Bothriechis snakebites in Colombia. A clinical and epidemiological study of 39 cases attended in a university hospital. Toxicon [Internet]. 2002;40(8):1107–14. Disponible en: http://dx.doi.org/10.1016/s0041-0101(02)00104-6
32. Silva FS, Ibiapina HNS, Neves JCF, Coelho KF, Barbosa FBA, Lacerda MVG, et al. Severe tissue complications in patients of Bothrops snakebite at a tertiary health unit in the Brazilian Amazon: clinical characteristics and associated factors. Rev Soc Bras Med Trop [Internet]. 2021;54. Disponible en: http://dx.doi.org/10.1590/0037-8682-0374-2020
2. Gutiérrez J. Snakebite envenomation in Central America. Epidemiology, pathophysiology and treatment. In: Mackessy S, ed. by. Handbook of Venoms and Toxins of Reptiles. 2nd ed. Boca Raton, Florida: CRC Press/Taylor and Francis Group; 2021. p. 543-558. Disponible en: https://www.taylorfrancis.com/chapters/edit/10.1201/9780429054204-41/snakebite-envenomation-central-america-jos%C3%A9-mar%C3%ADa-guti%C3%A9rrez
3. Houcke S, Resiere D, Lontsingoula GR, et al. Characteristics of Snakebite-Related Infection in French Guiana. Toxins (Basel). 2022;14(2):89. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878173/
4. Sasa M, Segura Cano S. New insights into snakebite epidemiology in Costa Rica: A retrospective evaluation of medical records. Toxicon: X. 2020;7:100055. Disponible en: https://www.sciencedirect.com/science/article/pii/S2590171020300333
5. Arroyo O, Rojas G, Gutiérrez J. Envenenamiento por mordedura de serpiente en Costa Rica en 1996: Epidemiología y consideraciones clínicas. Acta Médica Costarricense. 1999;41(4):23-29. Disponible en: https://actamedica.medicos.cr/index.php/Acta_Medica/article/view/528
6. Gutiérrez J, Calvete J, Habib A, Harrison R, Williams D, Warrell D. Snakebite envenoming. Nature Reviews Disease Primers. 2017;3(1). Disponible en: https://pubmed.ncbi.nlm.nih.gov/28905944/
7. Brenes-Chacón H, Ulloa-Gutierrez R, Soriano-Fallas A, Camacho-Badilla K, Valverde-Muñoz K, Ávila-Agüero ML. Bacterial Infections Associated with Viperidae Snakebites in Children: A 14-Year Experience at the Hospital Nacional de Niños de Costa Rica. Am J Trop Med Hyg. 2019;100(5):1227-1229. doi:10.4269/ajtmh.18-1015. Disponible en: https://pubmed.ncbi.nlm.nih.gov/30915952/
8. Criales J, Arguedas A. Infecciones bacterianas de tejidos blandos en niños mordidos por serpientes, en el Hospital Nacional de Niños, entre enero de 1988 y diciembre de 1992. Revista Medica Hospital Nacional de Niños Costa Rica. 1994;29:31-36.
9. Mendes V, Pereira H, Elias I, Soares G, Santos M, Talhari C et al. Secondary infection profile after snakebite treated at a tertiary referral center in the Brazilian Amazon. Revista da Sociedade Brasileira de Medicina Tropical. 2022;55. Disponible en: https://www.scielo.br/j/rsbmt/a/nJgnpJHgkWbmmY4DpxCZY4B/abstract/?lang=en
10. Résière D, Olive C, Kallel H, Cabié A, Névière R, Mégarbane B, Gutiérrez JM, Mehdaoui H. Oral Microbiota of the Snake Bothrops lanceolatus in Martinique. International Journal of Environmental Research and Public Health. 2018; 15(10):2122. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209983/
11. Jorge M, Mendonça J, Ribeiro L, Silva M, Kusano E, Cordeiro C. Flora bacteriana da cavidade oral, presas e veneno de Bothrops jararaca: possível fonte de infecção no local da picada. Revista do Instituto de Medicina Tropical de São Paulo. 1990;32(1):6-10. Disponible en: https://www.scielo.br/j/rimtsp/a/sRKZg5CXftGXbRTRyLLP84H/abstract/?lang=pt
12. Arroyo O, Bolaños R, Muñoz G. The bacterial flora of venoms and mouth cavities of Costa Rican snakes. Bull Pan Am Health Organ. 1980;14(3):280-285. https://pubmed.ncbi.nlm.nih.gov/7459511/
13. Artavia-León A, Romero-Guerrero A, Sancho-Blanco C, Rojas N, Umaña-Castro R. Diversity of Aerobic Bacteria Isolated from Oral and Cloacal Cavities from Free-Living Snakes Species in Costa Rica Rainforest. Int Sch Res Notices. 2017;2017:8934285. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585637/
14. Saravia-Otten P, Gutierrez JM, Arvidson S, Thelestam M, Flock JI. Increased infectivity of Staphylococcus aureus in an experimental model of snake venom-induced tissue damage. J Infect Dis. 2007;196(5):748-754. Disponible en: https://pubmed.ncbi.nlm.nih.gov/17674318/
15. Andrade J, Pinto R, Andrade A, Martelli C, Zicker F. Estudo bacteriológico de abscessos causados por picada de serpentes do genero bothrops. Revista do Instituto de Medicina Tropical de São Paulo. 1989;31(6):363-367. Disponible en: https://www.scielo.br/j/rimtsp/a/KV8g3tLLGJFcxPRKhRbjTMr/?lang=pt
16. Jorge MT, Ribeiro LA, da Silva ML, Kusano EJ, de Mendonça JS. Microbiological studies of abscesses complicating Bothrops snakebite in humans: a prospective study. Toxicon. 1994;32(6):743-748. Disponible en: https://pubmed.ncbi.nlm.nih.gov/7940580/
17. Resiere D, Gutiérrez JM, Névière R, Cabié A, Hossein M, Kallel H. Antibiotic therapy for snakebite envenoming. J Venom Anim Toxins Incl Trop Dis. 2020;26:e20190098. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011479/
18. Wagener M, Naidoo M, Aldous C. Wound infection secondary to snakebite. S Afr Med J. 2017;107(4):315-319. Disponible en: https://pubmed.ncbi.nlm.nih.gov/28395682/
19. Muñoz PA, Ovares AC. Antibioticoterapia profiláctica en el accidente ofídico: evidencia actual. Rev Med Cos Cen. 2010;67(593):251-254.
20. Stevens, D.L.; Bisno, A.L.; Chambers, H.F.; Dellinger, E.P.; Goldstein, E.J.C.; Gorbach, S.L.; Hirschmann, J.V.; Kaplan, S.L.; Montoya, J.G.; Wade, J.C. Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections: 2014 Update by the Infectious Diseases Society of America. Clin. Infect. Dis. 2014, 59, 147–159. Disponible en: https://academic.oup.com/cid/article/59/2/e10/2895845
21. Sachett JAG, da Silva IM, Alves EC, et al. Poor efficacy of preemptive amoxicillin clavulanate for preventing secondary infection from Bothrops snakebites in the Brazilian Amazon: A randomized controlled clinical trial. PLoS Negl Trop Dis. 2017;11(7):e0005745. Disponible en: https://pubmed.ncbi.nlm.nih.gov/28692641/
22. Instituto Clodomiro Picado. El envenenamiento por mordedura de serpiente en Centroamérica [Internet]. San José, Costa Rica: Facultad de Microbiología, Universidad de Costa Rica; 2009 [cited 13 June 2022]. Disponible en: https://hdl.handle.net/10669/30344
23. Resiere D, Mehdaoui H, Névière R, et al. Infectious Complications Following Snakebite by Bothrops lanceolatus in Martinique: A Case Series. Am J Trop Med Hyg. 2020;102(1):232-240. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947800/
24. T. Jorge S. de A. Nishioka R. B. de M. Aeromonas hydrophila soft tissue infection as a complication of snake bite: report of three cases. Ann Trop Med Parasitol [Internet]. 1998;92(2):213–7. Disponible en: http://dx.doi.org/10.1080/00034989860067
25. Soares Coriolano Coutinho JV, Fraga Guimarães T, Borges Valente B, Gomes Martins de Moura Tomich L. Epidemiology of secondary infection after snakebites in center-west Brazil. PLoS Negl Trop Dis [Internet]. 2023;17(3):e0011167. Disponible en: http://dx.doi.org/10.1371/journal.pntd.0011167
26. Sachett J de AG, Vieira SSC, Soares FGS, Alcântara JA, Carvalho HB de S, da Silva EMG, et al. Treatment of a snakebite injury with secondary bacterial infection: A case study. J Wound Ostomy Continence Nurs [Internet]. 2023;50(3):245–9. Disponible en: http://dx.doi.org/10.1097/won.0000000000000963
27. Cavalcante TTA, de Souza MBS, Neves JCF, Ibiapina HNS, Barbosa FBA, Bentes KO, et al. Inflammatory profile associated with secondary infection from Bothrops atrox snakebites in the Brazilian Amazon. Toxins (Basel) [Internet]. 2023;15(9):524. Disponible en: http://dx.doi.org/10.3390/toxins15090524
28. Larréché S, Bousquet A, da Silva L, Planelles A, Ksas R, Mérens A, et al. Antibiotic susceptibility of cultivable microbiota from the oral cavity of captive Bothrops atrox and Bothrops lanceolatus: Implications for the treatment of snakebite-associated infections in the French departments of America. Infect Dis Now [Internet]. 2023;53(7):104721. Disponible en: https://doi.org/10.1016/j.idnow.2023.104721
29. Brenes-Chacon H, Gutierrez JM, Camacho-Badilla K, Soriano-Fallas A, Ulloa-Gutierrez R, Valverde K, et al. Long-term sequelae secondary to snakebite envenoming: a single centre retrospective study in a Costa Rican paediatric hospital. BMJ Paediatr Open [Internet]. 2020;4(1):e000735. Disponible en: http://dx.doi.org/10.1136/bmjpo-2020-000735
30. Bucaretchi F, Herrera SRF, Hyslop S, Baracat ECE, Vieira RJ. Snakebites by Bothrops spp in children in Campinas, São Paulo, Brazil. Rev Inst Med Trop Sao Paulo [Internet]. 2001;43(6):329–33. Disponible en: http://dx.doi.org/10.1590/s0036-46652001000600006
31. Otero R, Gutiérrez J, Beatriz Mesa M, Duque E, Rodrı́guez O, Luis Arango J, et al. Complications of Bothrops, Porthidium, and Bothriechis snakebites in Colombia. A clinical and epidemiological study of 39 cases attended in a university hospital. Toxicon [Internet]. 2002;40(8):1107–14. Disponible en: http://dx.doi.org/10.1016/s0041-0101(02)00104-6
32. Silva FS, Ibiapina HNS, Neves JCF, Coelho KF, Barbosa FBA, Lacerda MVG, et al. Severe tissue complications in patients of Bothrops snakebite at a tertiary health unit in the Brazilian Amazon: clinical characteristics and associated factors. Rev Soc Bras Med Trop [Internet]. 2021;54. Disponible en: http://dx.doi.org/10.1590/0037-8682-0374-2020
Barra lateral del artículo
Publicado
sept 12, 2024
Detalles del artículo
Cómo citar
Campos-Ulate, A., Fres-Miranda, B., Bolívar-Zúñiga, J., Gamboa-Alvarado, J., & Casasola-Salas, W. (2024). Antibioticoterapia y microorganismos asociados a infección por mordedura de serpientes en Costa Rica y Latinoamérica . Revista Hispanoamericana De Ciencias De La Salud, 10(2), 92–103. https://doi.org/10.56239/rhcs.2024.102.765
Sección
Artículos de Revisión
Esta obra está bajo una licencia internacional Creative Commons Atribución-CompartirIgual 4.0.
La RHCS usa la licencia Creative Commons 4.0 Internacional (CC BY 4.0). Para obtener más información, visite https://creativecommons.org/licenses/by/4.0/