Clinical characterization of the Guillain-Barré Syndrome in the Mexico hospital, Costa Rica
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Keywords
Guillain-Barre syndrome, Miller Fisher Syndrome, acute demyelinating polyneuropathy, mortality, acute paralysis
Abstract
Guillain Barre Syndrome is a neurological disorder of immunological basis, generally behaves like an acute polyneuropathy, inflammatory and demyelinating. The clinical course and its complications, and the resulting degree of disability are varied, but its mortality is low. Objective: To investigate the epidemiological characteristics of patients diagnosed with Guillain-Barre Syndrome in the Hospital Mexico as well as its clinical manifestations during the period of the second half of 2011 to the first half of 2015. Materials and methods: A descriptive retrospective study was performed. Became a search for records of patients diagnosed with Guillain Barre Syndrome, the population consisted of 64 in-patient records, which were used for data analysis. Results: There was a predominance of males (58%) than female. The months with the highest frequency of occurrence was May and July. Acute diarrhea was the most frequently identified precipitating event (35.9%). Ascending weakness was the most common clinical pattern with 84.4% of cases. AMAN was the most common variant (28.13%), followed by AMSAN variant (15.63%). Mechanical ventilation was required in12.5% of patients and mortality reported was 3.13%. Gamma globulin treatment was the most used at 90.6% of cases. Conclusions: The clinical characteristics of Guillain-Barré syndrome are very similar to other reports. However, in our study the AMAN variant was the most frequent. The need for VMA and mortality was lower than that reported in the literature.
References
2. Van den Berg, B. Walgaard C, Drenthen J, et al. Guillain–Barré syndrome: pathogenesis, diagnosis, treatment and prognosis. Nat Rev. Neurol 2014, 10: 469–482.
3. Govoni V, Granieri E. Epidemiology of the Guillain-Barré syndrome. Curr Opin Neurol 2001, 14(5):605-613
4. Van Doorn PA, Ruts L, Jacobs BC. Clinical features, pathogenesis, and treatment of Guillain-Barré syndrome. Lancet Neurol 2008, 7(10): 939-950.
5. Dimachkie MM1, Barohn RJ. Guillain-Barré syndrome and variants. Neurol Clin 2013;31(2):491-510.
6. Tam CC, Rodrigues LC, Petersen I, Islam A, Hayward A, O'Brien SJ. Incidence of Guillain-Barré syndrome among patients with Campylobacter infection: a general practice research database study. J Infect Dis 2006, 1;194(1):95-7.
7. Winer JB. Treatment of Guillain-Barré syndrome. QJM 2002, 95(11):717-21.
8. França MC Jr, Deus-Silva L, de Castro R, Garibaldi SG,et al. Guillain-Barré syndrome in the elderly: clinical, electrophysiological, therapeutic and outcome features. Arq Neuropsiquiatr 2005, 63(3B):772-5.
9. González-Suárez I, Sanz-Gallego I, Rodríguez de Rivera FJ, Arpa J. Guillain-Barre Syndrome: Natural history and prognostic factors: a retrospective review of 106 cases. BMC Neurol. 2013, Jul 22;13(1):95.
10. van den Berg B, Bunschoten C, van Doorn PA, Jacobs BC. Mortality in Guillain-Barre syndrome. Neurology2013, Apr 30;80(18):1650-4.
11. Carrillo-Pérez Diego, García-Ramos Guillermo, Ruano-Calderón Luis A, et al. Síndrome de Guillain-Barré en un hospital de referencia en México. Rev Mex Neuroci 2012; 13 (1): 15-21.
12. Sánchez Javier, Chao Luken, Chávez Juan A, et al. Caracterización clínica del Síndrome de Guillain Barré. Rev Cub Med Int Emerg 2012; 11 (2): 2398-2408.
13. Carrillo-Torres José H, Peña-Rios Daniel H. Síndrome de Guillain-Barré en el Hospital General del Estado de Sonora: revisión de casos entre los años 2007 a 2011. Med Int Mex 2013; 29: 458-468.
14. Quintero Contreras TJ. Síndrome de Guillain Barré: estudio clínico y epidemiológico, Hospital San Juan de Dios 1994-1998. [Tesis: Posgrado de Medicina Interna]. San José (Costa Rica); Universidad de Costa Rica, 1999, p.20.
15. Paredes Rodríguez D. Síndrome de Guillain Barré en Hospital Calderón Guardia, periodo del 2000 al 2004. [Tesis: Especialidad en Cuidado Intensivo y Medicina Crítica]. San José (Costa Rica); Universidad de Costa Rica, 2006, p.80.
16. Sattler Sandoval R. Perfil epidemiológico de los pacientes con Síndrome de Guillain Barré, en el Hospital San Juan de Dios, de Enero de 2000 a diciembre de 2010: un estudio observacional y retrospectivo. [Tesis: Especialidad en Medicina Interna], San José (Costa Rica); Universidad de Costa Rica, 2013, p.20.
17. Dorado Arias Y. Síndrome de Guillain-Barré: características epidemiológicas y su asociación con infecciones respiratorias y diarreicas en el Hospital Calderón Guardia, periodo 2007-2011. [Tesis: Especialidad en Medicina Interna]. San José (Costa Rica); Universidad de Costa Rica, 2013, p.41.