Acute Liver Failure Induced by Mushroom Poisoning: A Narrative Review
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Keywords
Acute Liver Failure, Mushroom Poisoning, Amanita, Hepatic necrosis
Abstract
Accidental mushroom ingestion is an infrequent but severe cause of acute liver failure, particularly when mushrooms from the Amanita genus are involved. These mushrooms contain cyclopeptide toxins, such as phallotoxins and amatoxins, which inhibit RNA polymerase II, blocking protein synthesis and leading to cellular necrosis. Clinical manifestations vary widely, ranging from asymptomatic cases to multiple organ failure and death. Current treatment focuses on supportive care, as there is no universally accepted specific management.
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